Chapter 9: Physical Exercise


1. Katzmarzyk PT, Gledhill N, Shephard RJ. The economic burden of physical inactivity in Canada. CMAJ 2000;163(11):1435-40.
Rock A. The Toronto Star. August 2000.
2. Goodrick K. Baylor College of Medicine, Houston. 2001.
3. McGuire DK, Levine BD, Williamson JW, et al. A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise. Circulation 2001;104(12):1350-7.
McGuire DK, Levine BD, Williamson JW, et al. A 30-Year Follow-Up of the Dallas Bed Rest and Training Study. II. Effect of Age on Cardiovascular Adaptation to Exercise Training. Circulation 2001;104:1358-1366. (doi: 10.1161/hc3701.096099)
4. Sharp NCC, Koutedakis Y. Sport and the overtraining syndrome: immunological aspects. British Medical Bulletin 1992;48(3):518-533.
Speedy DB, Noakes TD, Holtzhausen LM. Exercise-associated collapse – Postural hypotension, or something deadlier? Physician and Sportsmedicine 2003;31(3):23-29.
Uusitalo ALT. Overtraining: making a difficult diagnosis and implementing targeted treatment. Phys Sportsmed 2001;29(5):35-50.
5. Kramer AF. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 2006;61(11):1166-70.
Churchill JD, Galvez R, Colcombe S,Swain RA, Kramer AF, Greenough WT. Exercise, experience and the aging brain. Neurobiol Aging 2002;23(5):941-55.
Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, et al. Neurobiology of exercise. Scand J Med Sci Sports 2006;16(6):470.
Kramer AF, Erickson KI, Colcombe SJ. Exercise, cognition, and the aging brain. J Appl Physiol 2006;101(4):1237-42. Epub 2006 Jun 15. Review.
6. Khatri P, Blumenthal JA, Babyak MA, et al. Effects of exercise training on cognitive functioning among depressed older men and women. Journal of Aging and Physical Activity 2001;9:43-57.
BlumenthalJA, Babyak MA, Moore KA, et al. Effects of exercise training on older patients with major depression. Archives of Internal medicine 1999;159(19):2349-56.
Dishman RK, Berthoud HR, Booth FW, et al. Physical activity dose-response effects on outcomes of depression and anxiety. Med Sci Sports Exerc 2001;33(6)(suppl):S587-S597.
Williams P, Lord SR. Effects of group exercise on cognitive functioning and mood in older women. Australian and New Zealand Journal of Public Health 1997;21(1):45-52.
Neeper SA. Exercise and brain neurotrophins. Nature 1995;373:109.
7-8. van Praag H, Schinder AF, Christie BR. et al. Functional neurogenesis in the adult hippocampus. Nature 2002;415(6875):1030–1034.
Van Praag H, Christi BR, Sejnowski J, et al. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13427–13431.
Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 2004;85:1694-704.
Mattson MP. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Research 2000;886:47-53.
Van Praag H. Gage F. Running increases cell proliferation, neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999;2:266-70.
Kiraly MA, Kiraly SJ. The effect of exercise on hippocampal integrity. Int’l J Psychiatry in Medicine 2005;35(1):75-89.
9. Cohen AD, Zigmond MJ, Smith AD. Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration. Brain Res 2011;1370:80-8. (doi: 10.1016/j.brainres.2010.11.006. Epub 2010 Nov 6).
Cohen AD, Tillerson JL, Smith AD, Schallert T, Zigmond MJ. Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF. J Neurochem 2003;85(2):299-305.
Tillerson JL, Cohen AD, Caudle WM, Zigmond MJ, et al. Forced nonuse in unilateral parkinsonian rats exacerbates injury. J Neurosci 2002;22(15):6790-9.
Tillerson JL, Cohen AD, Philhower J, Miller GW, Zigmond MJ, Schallert T. Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. J Neurosci 2001;21(12):4427-35.
10. Sasco AJ, Paffenberger RS Jr, Gendre I, Wing AL. The role of physical exercise in the occurrence of Parkinson’s disease. Arch Neurol 1992;49(4):360-5.
Kuroda K, Tatara K, Takatorige T, Shinsho F. Effect of physical exercise on mortality in patients with Parkinson’s disease. Acta Neurol Scand 1992;86(1):55-9.
Cadet P, Zhu W, Mantione K, et al. Cyclic exercise induces anti-inflammatory signal molecule increases in the plasma of Parkinson’s patients. Int J Mol Med 2003;12(4):485-92.
11. O’Brien-Cousins S. Strength to age better: Findings from the fit for your life project. Mature medicine (Canada);January-February:30-33.
Fiatarone Singh AN. Exercise and aging. Clin Geriatr Med 2004;20:201-221.
12. Brink S. Smart moves: new research suggests that folks from 0 to 80 can shape up their brains with aerobic exercise. US World and News Report, 1995;118(19):76-82.
Christensen H, Mackinnon A. The association between mental, social and physical activity and cognitive performance in young old subjects. Age Ageing 1993;22(3):175-82.
Berlin AA, et al. Depressive mood symptoms and fatigue after exercise withdrawal. Psychosom Med 2006;68:224-30.
Brody J. Good habits outweigh gene as key to healthy old age. New York Times 1996;February 28.
Depp CA, Jeste DV. Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. Am J Geriatr Psychiatry 2006;14:6-20.
King D. Exercise seen boosting children’s brain function. Boston Globe 1999; November 9. (Boston Conference: Learning and the Brain, Dr. John J. Ratey, Harvard Medical School, Department of Psychiatry).
Satoh et al. Walking exercise and improved neurophysiological functioning in elderly patients with Alzheimer’s Disease. J Int Med 1995;238(5):423.
13. Fiatarone Singh AN. Exercise and aging. Clin Geriatr Med 2004;20:201-221.
Cairney J, Faulkner G, Veldhuizen S, Wade TJ. Changes over time in physical activity and psychological distress among older adults. Can J Psychiatry 2009;54(3):160-69.
Studenski S, Carlson MC, Fillit H, Greenough WT, Kramer A, Rebok GW. From bedside to bench: does mental and physical activity promote cognitive vitality in late life? Sci Aging Knowledge Environ 2006 Jun 28;2006(10):pe21. Review.
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Accessed on August 29, 2015:

American College of Sports Medicine. ACSM’s Guidelines for exercise testing and Prescription. 6th ed. Baltimore: Lippincott, Williams & Wilkins. 2000.
Canadian Government Publishing Center, 5BX Plan for Physical Fitness (also 10BX Plan)
Hargreaves M: Exercise Metabolism. Champaign, IL: Human Kinetics Publishers, 1995.
Harris R, Harris S. Aging and Sports. Scientific and Medical Research. vol. 1., Albany, New York: Center for the Study of Aging, 1989.
O´Brien Cousins S. Active Living Among Older Adults: Health benefits and outcomes. Brunner Mazel, Philadelphia, 1999. (Summary and meta-analysis of 1,500 research articles 1990-1994). O’Brien Cousins S. Exercise, Aging and Health. University of Alberta, Brunner/Mazel, Philadelphia, PA. 1998.
Surgeon General’s Report: Physical Activity and Health. 1996. US Department of Health and Human Services. Centers for Disease Control and Prevention. Superintendent of Documents, PO. Box 371954, Pittsburgh, PA, 15250-7954. USA.
Tudor-Locke C. Manpo-Kei – The Art and Science of Step Counting: How to be naturally active and lose weight! Trafford Publishing, Victoria, Canada. 2003.

Reviewed on August 29, 2015