Chapter 8: Nutrition
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11. In Western Europe and the USA, 0.5% of the population becomes obese each year. In China and Brazil, 1.0%. In Mexico and S. Korea, 2.5% (ca. late 1990s). In India 33% of women are malnourished, 12% obese, even within the same household. India – obesity in same household. ? GR
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14. 60 Minutes, May 4,2014, — Dr. Kawa 90+ study: http://www.mind.uci.edu/research/90plus-study/
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Andersen LF, Jacobs JR. DR, Carlsen MH, Blumhoff R. Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women’s Health Study. Am J Clin Nutr 2006;83(5):1039-1046.
Ming Ding, Bhupathiraju SN, Satija A, et al. Long-term coffee consumption and risk of cardiovascular disease. A systematic review and dose-response meta-analysis of prospective cohort studies. Circulation 2014;129:643-659.
19. Scottish Health Survey: http://www.gov.scot/Topics/Statistics/Browse/Health/scottish-health-survey
Dr. Sarah Jarvis: http://heartuk.org.uk/about-us/celebrity-ambassadors/dr_sarah_jarvis
Cornelis MC, et al. 2006. Reported in: Jenkins D. Coffee and the heart – It’s all about genes. Parkhurst Exchange 2006;November:19.
Yesil A, Yilmaz Y. Aliment Pharmacol Ther 2013;38(9):1038-44. Coffee consumption may modulate risk of metabolic syndrome and non-alcoholic fatty liver.
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James JE. Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosomatic Medicine 2004;66:63-71.
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20. A recent study from Harvard School of Public Health showed that people who drink a cup of coffee six or more times a day may reduce their risk of diabetes by more than 50%.20 – GR
21. During the Nurse’s Health Study cohort involving 84,276 women from 1980 to 1998, coffee consumption was documented every 2-4 years through validated questionnaires. The researchers found an inverse relationship; the more coffee consumed the lower the incidence of diabetes. GR
Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ, Hu FB. Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med 2004 Jan 6;140(1):1-8. Summary for patients in: Ann Intern Med 2004 Jan 6;140(1):I17.
22. The Health Professional Study of 41,934 men, aged 40-75 were followed with food frequency surveys and asked to report diabetes diagnosis between 1986 and 1998. Results were similar to that of the Nurse’s Health Study. GR
23. Reported in: Cristafaro A. In praise of tea – Popular beverage packs a powerful antioxidant punch. Parkhurst Exchange 2005;April:113.
Cabrera C, Artacho R, Gimenez R. Beneficial effects of green tea–a review. J Am Coll Nutr 2006 Apr;25(2):79-99.
Biali S. Green tea: the best beverage on earth? The Medical Post 2008;August:21.
24. Reported in: Cristafaro A. In praise of tea – Popular beverage packs a powerful antioxidant punch. Parkhurst Exchange 2005;April:113.
25. Basu A, Lucas EA. Mechanism and effects of green tea on cardiovascular health. Nutrition Reviews 2007;65(8):361-375.
Cheng TO. All teas are not created equal: the Chinese green tea and cardiovascular health. Int J Cardiol 2006 Apr 14;108(3):301-8. Epub 2005 Jun 22.
Peters U, et al. Does tea affect cardiovascular disease? Am J Epidemiol 2001;154:495-503.
26. Schmidt A, Hammann F, Wolnerhanssen B, et al. Green tea extract enhances parieto-frontal connectivity during working memory processing. Psychopharmacology 2014 March 19. [Epub ahead of print]
27. Okello EJ, Leylabi R, McDougall GJ. Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites. Food Funct 2012;3(6):651-61.
Okello EJ, McDougall GJ, Kumar S, Seal CJ. In vitro protective effects of colon-available extract of Camellia sinensis (tea) against hydrogen peroxide and beta-amyloid (Aβ((1-42))) induced cytotoxicity in differentiated PC12 cells. Phytomedicine 2011;18(8-9):691-6.
Okello EJ, Savelev SU, Perry EK. In vitro anti-beta-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia. Phytother Res 2004;18(8):624-7.
28. Kao YH, Chang HH, Lee MJ, Chen CL. Tea, obesity, and diabetes. Mol Nutr Food Res 2006 Feb;50(2):188-210.
Wolfram S, Wang Y, Thielecke F. Anti-obesity effects of green tea: from bedside to bench. Mol Nutr Food Res 2006 Feb;50(2):176-87.
A Taiwanese study found a correlation between steady long term tea consumption and low body fat but it is not known whether tea really causes fat loss. GR.
29. Bruinsma K, Taren DL. Chocolate: food or drug? J Am Diet Assoc 1999;99(10):1249-56.
Chocolate cravings are often episodic and fluctuate with hormonal changes just before and during the menstrual cycle, suggesting a hormonal link and confirming the assumed gender-specific nature of chocolate cravings. GR
30. Milne C. For hypertensives, a dietary change that’s easy to swallow. Eating chocolate found to lower blood pressure. The Medical Post 2007;Sep18:25.
Schieszer J. Cocoa flavanols may boost vascular function. The Medical Post 2010;Aug3:33.
Flammer AJ, Hermann F, Sudano I, et al. Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation 2007;116:2376-2382.
Engler MB, Engler MM. The emerging role of flavonoid-rich cocoa and chocolate in cardiovascular health and disease. Nutrition reviews 2006;64(3):109-118.
In an Italian study, participants who ate 3.5 ounces of dark chocolate daily for 15 days had a 12 mmHg decrease in systolic blood pressure and a 9 mmHg drop in diastolic blood pressure compared to those who ate white chocolate. GR.
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32. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA 2006;103(4):1024-9. Epub 2006 Jan 17.
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High blood pressure develops in those who move to the mainland and start drinking commercial cocoa. GR
33. Grant D. ‘Super chocolate’ in the works. The Medical Post 2007;Sep18:25.
33.1. Won Lee K, Jun Kim Y, Joo Lee H, Yonh Lee C. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem 2003;51:7292-95.
34. Hines LM, Stampfer MJ, Ma J, et al. Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption in myocardial infarction. N Engl J Med 2001;344(8):549. Studies show that about five out of six Caucasians of European ancestry seem to benefit from moderate alcohol consumption. They can certainly tolerate higher amounts than the other people. GR
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Hines LM, Stampfer MJ, Ma J, et al. Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption in myocardial infarction. N Engl J Med 2001;344(8):549.
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36. Hedstrom AK, Hillert J, Olsson T, Alfredsson L. Alcohol as a Modifiable Lifestyle Factor Affecting Multiple Sclerosis Risk. JAMA Neurology. Published online January 6, 2014.
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38. At low levels it is not harmful, it may even give you a little benefit.” The international team was led by researchers from University of Victoria and the University of California. It analyzed 54 studies conducted from 1974 to 2004 linking how much people drink with risk of premature death from all causes, including heart disease. Researchers investigated an earlier claim that many studies about the link between moderate drinking and heart disease made a critical error. Those studies included as abstainers people who had reduced or quit drinking because of chronic illnesses, declining health, frailty, drug use or disability. When abstainers were compared with moderate drinkers, the imbibers came out slightly healthier. However, seven studies that compared moderate drinkers to long-term abstainers found no difference in risk of death.
Derzko C. “Not exercising, drinking three alcoholic beverages a day, or gaining 20 lbs. or being more than 20 lbs. overweight raises your risk of breast cancer 2 – 3 times as much as 10 years of being on HRT.” said by Dr. Christine Derzko, Director of the midlife menopause program at St. Michael’s Hospital in Toronto, quoted in “Healthy Woman”, Feb. March 2001.
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41. Cook NR, Cutler JA, Obarzanek E, et al. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ 2007;334:885-8.
A study showed that a low salt diet reduced blood pressure in those with normal blood pressure by an average of 7.1 mmHg and in those with high blood pressure by 11.5 mmHg. That was a randomized prospective study for 30 days involving 412 people. The researchers concluded that long-lasting dietary changes are most important.41 GR
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47. Vannier S. Low Vitamin C Linked to Intracerebral Hemorrhage. 66th Annual Meeting of the American Academy of Neurology. April 26-May 2, 2014 Abstract 3101. Reported in Medscape Medical News May 1, 2014.
48. Song J, Park J, Kim JH, Choi JY, et al. Dehydroascorbic Acid Attenuates Ischemic Brain Edema and Neurotoxicity in Cerebral Ischemia: An in vivo Study. Exp Neurobiol 2015 Mar;24(1):41-54.
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49.1 Some forms of cannabis have anti-convulsant effects: http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy. Accessed on July 21, 2015.
50. Buka I, Koranteng S. Lead Poisoning. Even low levels in children are unsafe. Parkhurst Exchange 2006;November:90-93.
51. Dawson EB, Evans DR, Harris WA, Teter MC, McGanity WJ. The effect of ascorbic acid supplementation on the blood lead levels of smokers. J Am Coll Nutr 1999 Apr;18(2):166-70.
52. It has been estimated that about 40% of people with tinnitus (ringing in the ears), are suffering from nitrate toxicity(52ef).
53. Mozaffarian D, Rimm EB. Fish intake, contaminants and human health: Evaluating the risks and benefits. JAMA 2006;296(15):1885-99.
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54. The recommended dietary allowance (RDA) was developed during World War II by Lydia J. Roberts, Hazel Stiebeling, and Helen S. Mitchell, all part of a committee established by the United States National Academy of Sciences in order to investigate issues of nutrition that might “affect national defense” (wikipedia.org). The committee was renamed the Food and Nutrition Board in 1941.
55. Optimal Daily Allowance (ODA) is not a fixed value like the RDA but a calculated value arrived at by taking into consideration a person’s age, gender, activity level, stress level, health status and BMI.
56. Van Way CW, Ireton-Jones C. Nutrition Secrets, 2nd Edition. Hanley & Belfus, Philadelphia. 2004. 6. Is a change in lean body mass a normal part of the aging process? Pp.51.
57. Scarmeats N, Stern Y, Mayeux R, et al. Mediterranean diet, Alzheimer disease and vascular mediation. Arch Neurol 2006;63:1709-1717.
58. Van Horn L, McCoin M, Kris-Etherton PM, et al. The evidence for dietary prevention and treatment of cardiovascular disease. J Am Diet Assoc 2008;108:287-331.
59. Lead investigator: Oyebode O, et al. BBC. April 1, 2014.
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61. Nurk E, Drevon CA, Refsum H, et al. Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr 2007;86:1470-8.
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Cite this article: Alan R. Jacobs. Fish Oil Slows Cognitive Decline, With Caveats. Medscape. Oct 09, 2014. Fish oils slows AD process in those who do not already have dementia.
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GR – A prospective study was conducted from 1993 through 2000, of a stratified random sample from a geographically defined community. Participants were followed up for an average of 3.9 years for the development of AD. A total of 815 residents, aged 65 to 94 years, who were initially unaffected by AD completed a dietary questionnaire on average 2.3 years before clinical evaluation of existing AD. Result: Consumption of the n-3-polyunsaturated fatty acids and fish was associated with reduced risk of incident AD in this large prospective study(61.
62. Koppal T, Drake J, Yatin S, et al. Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer’s disease. J Neurochem 1999;72:310-317.
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Carrie I, Clement M, de Javel D, Frances H, Bourre JM. Specific phospholipids fatty acid composition of brain regions in mice: effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. J Lipid Res 2000;41:465-472.
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63. Conquer JA, Tierney MC, Zecevic J, Bettger WJ, Fisher RH. Fatty acid analysis of blood plasma of patients with Alzheimer’s disease, other types of dementia, and cognitive impairment. Lipids 2000;35:1305-1312.
64. Gu Y, Nieves JW, Stern Y, et al. Food combination and Alzheimer disease risk. Arch Neurol 2010;67(6):699-706.
Scarmeas N. Washington Heights/Hamilton Heights Aging Project (WHICAP) Neurology 2012;May 2. Cite: Omega-3-rich diet may protect against Alzheimer’s disease. Medscape, May 4, 2012.
Also see: Alzheimer Dement 2011;7:S296-S297 and Arch Neurol 2006;October.
Chowdhury R, Stevens S, Gorman D, et al. Association between fish consumption, long chain omeg-3 fatty acids and risk of cerebrovascular disease: systematic review and meta-analysis. BMJ 2012;345:e6698 doi:10.1136/bmj.e6698.
GR – Other studies found that fish consumption was inversely associated with risk of incident AD.64
65. Jenkins DJ, Kendall CW, Marchie A, et al. Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA 2003;Jul 23;290(4):502-10.
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66. Mancini GBJ, Baker S, Bergeron J, et al. Diagnosis, prevention and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Conference. Canadian Journal of Cardiology 2011;27:635-662.
Reviewed on July 30, 2015